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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
The effect of heat stress on the induced hepatic drug metabolizing system in rats
The effect of heat stress on the induced hepatic drug metabolizing system in rats
 
الموضوع : علم الأدوية 
لغة الوثيقة : الانجليزية 
المستخلص : The activity of the hepatic oxidative drug metabolizing system has been investigated in an experimentally-induced heat stress animal model pretreated with phenobarbitone. Female rats, unacclimatized and untrained were pretreated for 3 days with phenobarbitone as the inducing agent for the drug metabolizing systems. On the fourth day, they were restrained and exposed to an ambient temperature of 40 degrees C. One hour after acute exposures to such conditions, the activities of hepatic cytochrome P450, cytochrome b5 and NADPH cytochrome c reductase were significantly decreased in the induced animal model. Further, cytochrome P450 isozymes observed by SDS-gel electrophoresis were significantly decreased. In addition, the hypnotic effect of pentobarbitone was significantly increased. It is concluded that the activity of the hepatic oxidative drug metabolizing enzymes was decreased in induced drug metabolism systems exposed to heat stress conditions 
ردمد : 0398-7639 
اسم الدورية : European Journal of Drug Metabolism and Pharmacokinetics 
المجلد : 27 
العدد : 2 
سنة النشر : 1422 هـ
2002 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Thursday, March 31, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
زهير دمنهوريDamanhouri, Zoheir باحثدكتوراه 

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اسم الملفالنوعالوصف
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