Document Details

Document Type : Article In Journal 
Document Title :
Effects of filaricidal drugs on longevity and enzyme activities of the microfilariae of Setaria cervi in white rats
تأثير العقاقير المضادة للفيلاريا على طول عمر وفاعلية انزيمات الفيلاريا سيتاريا كيرفي في الفئران البيضاء
 
Subject : Parasitology 
Document Language : English 
Abstract : Objective: To analyse the efficacy of diethylcarbamazine (DEC), tetramisole and chlorpromazine on the longevity and activity of glucose-6-phosphatase and succinate dehydrogenase in the microfilariae recovered from the peripheral circulation of the rats before and after the treatment. Methods: Setaria cervi worms were implanted in white rats via laparotomy and microfilaraemic rats were divided into 4 groups. Groups 1, 2 and 3 were treated with DEC, tetramisole and chlorpromazine respectively, while Group 4 served as infected control. Longevity of microfilariae and differential leucocyte counts were recorded till the disappearance of microfilariae from peripheral blood. Glucose-6-phosphatase and succinate dehydrogenase enzymes were localized in the microfilariae recovered from normal and treated rats. Results: The microfilariae survived for 48 days in untreated rats while survival was reduced to 15, 21 and 27 days after treatment with DEC, tetramisole and chlorpromazine, respectively. Eosinophils and neutrophils increased during 2nd and 3rd weeks, whereas the lymphocytes increased during 4-7 weeks. DEC treatment resulted in slight decrease in the localization of succinate dehydrogenase but not in glucose-6-phosphatase. Tetramisole and chlorpromazine treatment did not show any appreciable change in the localization of both the above enzymes. Conclusions: DEC proved the most effective drug which cleared the microfilaraemia within 15 days and reduced the activity of succinate dehydrogenase to some extent followed by tetramisole and chlorpromazine which took more time for the clearance of microfilariae and had no effect on the localization of both glucose-6-phosphatase and succinate dehydrogenase. 
ISSN : 2221-1691 
Journal Name : Asian Pacific Journal of Tropical Biomedicine 
Volume : 5 
Issue Number : 9 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Wednesday, September 2, 2015 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم أحمد زكائيZakai, Haytham AhmedInvestigatorDoctoratehzakai@kau.edu.sa
وجيه الله رضى الله خانKhan, Wajeehullah RedallahResearcherDoctoratewajihullahkhan@yahoo.co.in

Files

File NameTypeDescription
 38028.pdf pdfEffects of filaricidal drugs on longevity and enzyme activities of the microfilariae of Setaria cervi in white rats

Back To Researches Page